Each profile contains only the settings that are relevant for Microsoft Defender Antivirus for macOS and Windows devices, or for the user experience in the Windows Security app on Windows devices. Each antivirus policy includes several profiles. Antivirus policies help security admins focus on managing the discrete group of antivirus settings for managed devices. You can use Intune to configure antivirus policies, and then apply those policies across devices in your organization. Manage antivirus settings with Microsoft Intune Note that after troubleshooting mode ends, any changes made to tamper-protected settings are reverted to their configured state. If you must make changes to a device and those changes are blocked by tamper protection, we recommend using troubleshooting mode to temporarily disable tamper protection on the device. As a result, when tamper protection is enabled, any changes made to tamper-protected settings are ignored. Tamper protection helps keep always-on protection and other security settings from being changed.