How to Create an Autoresponder Email Reply in Mail for Mac OS As long as you have an email account added to the Mail app for Mac and have the Mail app open and running, the auto-reply will be sent. Setting up autoresponders in Mail for Mac works the same on basically every version of Mail app and Mac OS, so this should be version and release agnostic. This tutorial will show you how to set up an autoresponder just like that, from within the Mail app for Mac.
If you’ve ever sent someone an email and then received an immediate reply that said something like “I’m out of the office right now, please reach me on my cell phone at 55” then you have seen how an auto-responder email works.